【Abstract】Objective: to study the influence of sodium dimercaptosulfonate (Na-DMPS) on serum enzyme level of tertramine poisoned patients and its clinic curative efficiency. Methods: 56 cases of tertramine poisoning were divided into experimental group and controlled group. The patients in the controlled group were treated with diazepam and conventional therapy while those in the experimental group were treated with Na-DMPS, diazepam and conventional therapy. Serious poisoning cases were all treated with hemoperfusion. The change of the concentrations of serum creatine kinase (CK), creatine kinase MB (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH) and aspartate trasaminase (AST) before treatment and after 12 and 24 hours of treatment were analyzed and compared. The convulsion frequency of patients was also compared. Results: all the patients showed highly increased serum enzyme level before treatment. After treatment, the serum enzyme level of the experimental group were much more lowered than that of controlled group after treatment with significant difference (P<0.05)). The convulsion frequency of experimental group was also significantly reduced (P<0.01). Conclusion: tertramine poisoning seriously increased the serum enzyme level of the patients. Na-DMPS reduces both the serum enzyme level and convulsion frequency of the patients. Short-term recovery could also be improved by this method.